A dCTPase 1 inhibitor
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TH1217

Item No. 43599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-[N-[(carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]-boron
CAS Number
1862212-48-3
Synonyms
  • ZINC1775962367
Molecular Formula
C20H17BCl2N4O6
Formula Weight
491.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
C[N](C1)(C2)[B+3]([O-]C1=O)([C-](C=C3)=CC=C3CN(C(C)=NC4=C5[N+]([O-])=O)C4=CC(Cl)=C5Cl)[O-]C2=O
InChi Code
InChI=1S/C20H17BCl2N4O6/c1-11-24-19-15(7-14(22)18(23)20(19)26(30)31)25(11)8-12-3-5-13(6-4-12)21-27(2,9-16(28)32-21)10-17(29)33-21/h3-7H,8-10H2,1-2H3
InChi Key
HWFRCQHNILGMLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $168

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    25 mg

    $314

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    50 mg

    $523

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    Product Description

    TH1217 is an inhibitor of dCTP pyrophosphatase 1 (dCTPase 1; IC50 = 47 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Llona-Minguez, S., Höglund, A., Jacques, S.A., et al. Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J. Med. Chem. 59(3), 1140-1148 (2016).