A Piezo1 agonist
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Yoda2 (potassium salt)

Item No. 43639

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate, monopotasium salt
Synonyms
  • KC289
Molecular Formula
C16H9Cl2N2O2S2 • K
Formula Weight
435.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]
InChi Code
InChI=1S/C16H10Cl2N2O2S2.K/c17-12-2-1-3-13(18)11(12)8-23-16-20-19-14(24-16)9-4-6-10(7-5-9)15(21)22;/h1-7H,8H2,(H,21,22);/q;+1/p-1
InChi Key
OQEIWUHZUPFUQU-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $137

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    10 mg

    $248

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    Product Description

    Yoda2 is an agonist of Piezo1.1 It induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 150 nM). Yoda2 is selective for Piezo1 over 30 other ion channels and receptors at 5 µM. It induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50 = 1.2 µM). Yoda2 (5 µmol/kg) increases cortical area and thickness at 15 and 37% of the tibial bone length in combination with loading in 22-month-old female mice in a model of aging-induced loss of bone adaptation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parsonage, G., Cuthbertson, K., Endesh, N., et al. Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br. J. Pharmacol. 180(16), 2039-2063 (2023).

    2. Meslier, Q.A., Oehrlein, R., and Shefelbine, S.J. Combined effects of mechanical loading and piezo1 chemical activation on 22-months-old female mouse bone adaptation. Aging Cell (2025).