A Piezo1 agonist
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KC159

Item No. 43640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoic acid
Molecular Formula
C16H10Cl2N2O2S2
Formula Weight
397.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(O)C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1
InChi Code
InChI=1S/C16H10Cl2N2O2S2/c17-12-2-1-3-13(18)11(12)8-23-16-20-19-14(24-16)9-4-6-10(7-5-9)15(21)22/h1-7H,8H2,(H,21,22)
InChi Key
KFIUJWYVLYQUOY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $299

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    5 mg

    $598

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    10 mg

    $897

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    Product Description

    KC159 is an agonist of Piezo1.1 It induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 280 nM) and induces inward currents in a whole-cell patch-clamp assay using HEK cells overexpressing mouse Piezo1 when used at a concentration of 10 µM. KC159 induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50s = 1.14 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parsonage, G., Cuthbertson, K., Endesh, N., et al. Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br. J. Pharmacol. 180(16), 2039-2063 (2023).