For immunochemical detection of RSV F protein
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RSV F Protein Neutralizing Rabbit Monoclonal Antibody (Clone R338)

Item No. 43643

Product Insert (PDF)
Technical Information
Synonyms
  • Respiratory Syncytial Virus F Protein
  • Respiratory Syncytial Virus Fusion Protein
  • RSV Fusion Protein
Immunogen
Recombinant human-targeted RSV F protein
Clone Designation
R338
Formulation (Request formulation change)
200 or 500 µg of protein A-purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in histidine and arginine buffer with 120 mM sodium chloride, pH 6.0, and 0.02% polysorbate 80
Host
Rabbit
Isotype
IgG
Applications
WB, ELISA
Cross Reactivity
(+) RSVB pre-F(+) RSVB post-F(+) RSV pre-F (A2)(+) RSV post-F(+) RSV-F (A2)(+) RSV-F (strain RSS-2)(+) RSV-F (aa 1-525)(+) RSV-F (aa 1-526)(+) RSV-F (A, strain long)(+) RSV-F (B, strain 18537)
Species Reactivity
(+) RSV
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    200 µg

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    500 µg

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    Product Description

    Respiratory syncytial virus (RSV) fusion (F) protein is a surface glycoprotein encoded by the F gene in RSV RNA.1 It is synthesized as an inactive precursor protein, F0, that undergoes proteolytic cleavage to release the F1 and F2 subunits, which are joined together by two disulfide bonds.2 Mature RSV F protein is composed of an N-terminal fusion peptide (FP), two heptad repeats (HRs), a transmembrane domain, and a cytoplasmic tail and assembles into homotrimers on the virus surface.1 Upon insertion of the FP in the target cell membrane, the HRs form a six-helical bundle (6-HB) that enables RSV to fuse with the target cell. RSV F protein is highly conserved between RSV subtypes A and B with approximately 90% amino acid identities.3 RSV is the most common causative agent of pediatric lower respiratory tract infections.4 Cayman's RSV F Protein Neutralizing Rabbit Monoclonal Antibody (Clone R338) can be used for ELISA and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Graham, B.S., and Anderson, L.J. Challenges and opportunities for respiratory syncytial virus vaccines. Curr. Top. Microbiol. Immunol. 372, 391-404 (2013).

    2. Day, N.D., Branigan, P.J., Liu, C., et al. Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function. Virol. J. 3, 34 (2006).

    3. Choi, S.-H., Park, K.S., and Kim, Y.-J. Analysis of respiratory syncytial virus fusion protein from clinical isolates of Korean children in palivizumab era, 2009-2015. J. Infect. Chemother. 25(7), 514-519 (2019).

    4. Nair, H., Nokes, D.J., Gessner, B.D., et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis. Lancet 375(9725), 1545-1455 (2010).