A macrocyclic chelator
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Product Categories

Product Type

Biochemicals
Metal Chelators

Research Area

Cancer

DOTA

Item No. 43655

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number
60239-18-1
Synonyms
  • NSC 681107
  • Tetraxetan
Molecular Formula
C16H28N4O8
Formula Weight
404.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
OC(CN(CCN(CC1)CC(O)=O)CCN(CCN1CC(O)=O)CC(O)=O)=O
InChi Code
InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
InChi Key
WDLRUFUQRNWCPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    1 g

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    5 g

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    Product Description

    DOTA is a macrocyclic chelator.1 It has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wild, D., Schmitt, J.S., Ginj, M., et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur. J. Nucl. Med. Mol. Imaging 30(10), 1338-1347 (2003).

    2. Dam, J.H., Langkjær, N., Baun, C., et al. Preparation and evaluation of [18F]AlF-NOTA-NOC for PET imaging of neuroendocrine tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC. Molecules 27(20), 6818 (2022).