An NMDA receptor antagonist
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CGP 37849

Item No. 43660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4-methyl-5-phosphono-3E-pentenoic acid
CAS Number
127910-31-0
Molecular Formula
C6H12NO5P
Formula Weight
209.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble: ≥ 10 mg/ml
SMILES
O=P(O)(O)C/C(C)=C/C(N)C(O)=O
InChi Code
InChI=1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChi Key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $82

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    10 mg

    $156

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    25 mg

    $367

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    50 mg

    $692

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    Product Description

    CGP 37849 is an NMDA receptor antagonist (Ki = 220 nM).1 It decreases the number of seizures induced by maximal electroshock (MES) in rats (ED50 = 21 mg/kg). CGP 37849 (0.62, 1.25, or 2.5 mg/kg) reduces immobility time in the forced swim test.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fagg, G.E., Olpe, H.R., Pozza, M.F., et al. CGP 37849 and CGP 39551: Novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Br. J. Pharmacol. 99(4), 791-797 (1990).

    2. Jin, Q., Martinez, C.A., Arcipowski, K.M., et al. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia. Clin. Cancer Res. 25(1), 222-239 (2019).