A KCa1.1/BK activator
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NS 19504

Item No. 43669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(4-bromophenyl)methyl]-2-thiazolamine
CAS Number
327062-46-4
Molecular Formula
C10H9BrN2S
Formula Weight
269.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
BrC1=CC=C(CC2=CN=C(N)S2)C=C1
InChi Code
InChI=1S/C10H9BrN2S/c11-8-3-1-7(2-4-8)5-9-6-13-10(12)14-9/h1-4,6H,5H2,(H2,12,13)
InChi Key
HGWLTZOMQZIUBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $104

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    25 mg

    $242

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    50 mg

    $394

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    Product Description

    NS 19504 is an activator of large-conductance calcium-activated potassium channels (KCa1.1/BK).1 It induces currents in whole-cell patch-clamp assays using HEK293 cells expressing human KCa1.1/BK when used at a concentration of 10 µM. NS 19504 decreases the force of spontaneous phasic contractions in isolated and perfused guinea pig bladder smooth muscle strips (EC50 = 640 nM). It inhibits methoxamine-induced contractions in isolated rat saphenous arteries when used at a concentration of 6 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nausch, B., Rode, F., Jørgensen, S., et al. NS19504: A novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J. Pharmacol. Exp. Ther. 350(3), 520-530 (2014).

    2. Ma, D., Gaynullina, D., Schmidt, N., et al. The functional availability of arterial Kv7 channels is suppressed considerably by large-conductance calcium-activated potassium channels in 2- to 3-month old but not in 10- to 15-day old rats. Front. Physiol. 11, 597395 (2020).