An NMDA receptor antagonist
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SDZ 220-040

Item No. 43672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-amino-2′,4′-dichloro-4-hydroxy-5-(phosphonomethyl)-[1,1′-biphenyl]-3-propanoic acid
CAS Number
174575-40-7
Molecular Formula
C16H16Cl2NO6P
Formula Weight
420.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
ClC1=C(C=CC(Cl)=C1)C2=CC(C[C@H](N)C(O)=O)=C(C(CP(O)(O)=O)=C2)O
InChi Code
InChI=1S/C16H16Cl2NO6P/c17-11-1-2-12(13(18)6-11)8-3-9(5-14(19)16(21)22)15(20)10(4-8)7-26(23,24)25/h1-4,6,14,20H,5,7,19H2,(H,21,22)(H2,23,24,25)/t14-/m0/s1
InChi Key
NYZFUZCCDOSQBG-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $303

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    5 mg

    $832

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    10 mg

    $1,210

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    Product Description

    SDZ 220-040 is an NMDA receptor antagonist (apparent pA2 = 8.75).1 It reduces the number of convulsions induced by maximal electroshock (MES) in mice (ED50 = 3.2-10 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Müller, W., Kipfer, P., Lowe, D.A., et al. Syntheses of biphenyl analogues of AP7, a new class of competitive N-methyl-D-aspartate (NMDA) receptor antagonists. Helv. Chim. Acta 78, 2026-2035 (1995).

    2. Urwyler, S., Campbell, E., Fricker, G., et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology 35(6), 655-669 (1996).