Host: Insect cells • AA: 19-1,000 • Tag: C-terminal His • MW: 110 kDa
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Contactin-4 Long Isoform (human, recombinant)

Item No. 43688

Technical Information
Synonyms
  • BIG-2
  • Brain-derived Immunoglobulin Superfamily Protein 2
  • CNTN4
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU per µg of the protein as determined by the LAL method
Source
Recombinant human C-terminal His-tagged contactin-4 long isoform expressed in insect cells
Amino Acids
19-1,000
MW
110 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM tris, 300 mM sodium chloride, 10% glycerol, pH 8.5
UniProt Accession №
Q8IWV2
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $273

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    Cayman Chemical
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    Product Description

    Contactin-4 is a neural cell adhesion molecule and member of the immunoglobulin (Ig) superfamily.1 It is composed of six Ig-like repeats, four fibronectin type III-like domains, and a hydrophobic C-terminal sequence that contains a glycosylphosphatidylinositol (GPI) anchor site. Contactin-4 is ubiquitously expressed in the brain with the highest levels in the cerebellum but is also expressed in leukocytes, testis, spinal cord, and thyroid.2 It is involved in neurodevelopment, arborization, synaptic plasticity, and learning and memory and interacts with amyloid precursor protein (APP), amyloid-β precursor-like protein 1 (APLP-1), and protein tyrosine phosphatase γ (PTPγ).1,3,4 Disruption of CNTN4, the gene encoding contactin-4, is associated with developmental delay and dysmorphic features.5 Cayman’s Contactin-4 Long Isoform (human, recombinant) protein consists of 993 amino acids, has a calculated molecular weight of 110 kDa, and a predicted N-terminus of Asp19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 120-130 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oguro-Ando, A., Zuko, A., Kleijer, K.T.E., et al. A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders. Mol. Cell. Neurosci. 81, 72-83 (2017).

    2. Kamei, Y., Takeda, Y., Teramoto, K., et al. Human NB-2 of the contactin subgroup molecules: Chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. Genomics 69(1), 113-119 (2000).

    3. Osterhout, J.A., Stafford, B.K., Nguyen, P.L., et al. Contactin-4 mediates axon-target specificity and functional development of the accessory optic system. Neuron 86(4), 985-999 (2015).

    4. Oguro-Ando, A., Bamford, R.A., Sital, W., et al. Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Transl. Psychiatry. 11(1), 106 (2021).

    5. Fernandez, T., Morgan, T., Davis, N., et al. Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. Am. J. Hum. Genet. 74(6), 1286-1293 (2004).