Host: HEK293 cells • AA: 19-1,059 • Tag: C-terminal His • MW: 116 kDa
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Contactin-5 Long Isoform (human, recombinant)

Item No. 43689

Product Insert (PDF)
Technical Information
Synonyms
  • CNTN5
  • hNB-2
  • Neural Recognition Molecule NB-2
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg, determined by the LAL endotoxin assay
Source
Recombinant human C-terminal His-tagged contactin-5 long isoform expressed in HEK293 cells
Amino Acids
19-1,059
MW
116 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
Host
HEK293 cells
UniProt Accession №
O94779
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $273

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    Product Description

    Contactin-5 is a neural cell adhesion molecule and member of the immunoglobulin (Ig) superfamily.1 It is composed of six Ig-like repeats, four fibronectin type III-like domains, and a hydrophobic C-terminal sequence that contains a glycosylphosphatidylinositol (GPI) anchor site. Contactin-5 is primarily expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus, and temporal lobe of the brain but is also expressed in the thyroid.2 It is involved in neurodevelopment, arborization, and sensory terminal function and interacts with amyloid-β precursor-like protein 1 (APLP-1), protein tyrosine phosphatase γ (PTPγ), and contactin-associated protein-like 4 (CNTNAP4).1,3 A SNP in CNTN5, the gene encoding contactin-5, is associated with increased risk and disease progression in patients with sporadic Alzheimer’s disease.4 Cayman’s Contactin-5 Long Isoform (human, recombinant) protein consists of 1,052 amino acids, has a calculated molecular weight of 116 kDa, and a predicted N-terminus of Glu19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 130-140 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oguro-Ando, A., Zuko, A., Kleijer, K.T.E., et al. A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders. Mol. Cell. Neurosci. 81, 72-83 (2017).

    2. Kamei, Y., Takeda, Y., Teramoto, K., et al. Human NB-2 of the contactin subgroup molecules: Chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. Genomics 69(1), 113-119 (2000).

    3. Shimoda, Y., and Watanabe, K. Contactins: Emerging key roles in the development and function of the nervous system. Cell Adh. Migr. 3(1), 64-70 (2009).

    4. Dauar, M.T., Labonté, A., Picard, C., et al. Characterization of the contactin 5 protein and its risk-associated polymorphic variant throughout the Alzheimer’s disease spectrum. Alzheimers Dement. 19(7), 2816-2830 (2023).