Host: HEK293 cells • AA: 20-999 • Tag: C-terminal human IgG Fc • MW: 135.3 kDa
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Contactin-6 (human, recombinant)

Item No. 43690

Product Insert (PDF)
Technical Information
Synonyms
  • CNTN6
  • hNB-3
  • Neural Recognition Molecule NB-3
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU per μg protein as determined by the LAL method
Source
Recombinant C-terminal human IgG1 Fc-tagged contactin-6 expressed in HEK293 cells
Amino Acids
20-999
MW
135.3 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q9UQ52
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $237

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    Product Description

    Contactin-6 is a neural cell adhesion molecule and member of the immunoglobulin (Ig) superfamily.1 It is composed of six Ig-like repeats, four fibronectin type III-like domains, and a hydrophobic C-terminal sequence that contains a glycosylphosphatidylinositol (GPI) anchor site. Contactin-6 is ubiquitously expressed in the brain with the highest levels in the cerebellum.2 It is involved in neuronal apoptosis, axon regeneration in response to injury, and dendrite orientation.3,1 Contactin-6 forms stabilized interactions with proteins such as latrophilin-1, Notch, and protein tyrosine phosphatase α (PTPα), PTPγ, and PTPσ, and binds to them in either cis or trans. Homozygous knockout of CNTN6, the gene encoding contactin-6, in male mice decreases contactin-6 levels in the accessory olfactory system and reduces mating preference toward estrous female mice.4 Cayman’s Contactin-6 (human, recombinant) protein consists of 1,218 amino acids, has a calculated molecular weight of 135.3 kDa, and a predicted N-terminus of Asp20 after signal peptide cleavage.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oguro-Ando, A., Zuko, A., Kleijer, K.T.E., et al. A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders. Mol. Cell. Neurosci. 81, 72-83 (2017).

    2. Kamei, Y., Tsutsumi, O., Taketani, Y., et al. cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human. J. Neurosci. Res. 51(3), 275-283 (1998).

    3. Zuko, A., Oguro-Ando, A., Post, H., et al. Association of cell adhesion molecules contactin-6 and latrophilin-1 regulates neuronal apoptosis. Front. Mol. Neurosci. 9, 143 (2016).

    4. Zhang, W., Huang, H., Gui, A., et al. Contactin-6-deficient male mice exhibit the abnormal function of the accessory olfactory system and impaired reproductive behavior. Brain Behav. 13(4), e2893 (2023).