Host: E. coli • AA: 2-242 (full length) • Tag: N-terminal His • MW: 28.5 kDa
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Caspase-14 (human, recombinant)

Item No. 43693

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CASP-14
  • MICE
  • Mini-interleukin-1 Converting Enzyme
Purity
≥95% estimated by SDS-PAGE
Source
Recombinant human N-terminal His-tagged caspase-14 expressed in E. coli
MW
28.5 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4, with 5% trehalose, 5% mannitol, and 0.01% polysorbate 80
Host
E. coli
Applications
2-242 (full length)
UniProt Accession №
P31944
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    Product Description

    Caspase-14 is a cysteinyl aspartic protease.1,2,3 It is expressed during embryonic development and in differentiating keratinocytes and localizes to the cytoplasm and nucleus.2,3 Caspase-14 is produced as a zymogen containing a large and small subunit and is activated via proteolytic cleavage by kallikrein 7 (KLK7).4 It is involved in keratinocyte differentiation, cornification, UVB protection, and profilaggrin degradation.1 A SNP in CASP14, the gene encoding caspase-14, is associated with ichthyosis.5 Cayman’s Caspase-14 (human, recombinant) protein consists of 248 amino acids and has a calculated molecular weight of 28.5 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 30 kDa.

    WARNING This product is not for human or veterinary use.