FPPS Short Isoform (human, recombinant)

Farnesyl diphosphate synthase (FPPS) is a prenyltransferase and a member of the farnesyl pyrophosphate/geranylgeranyl pyrophosphate (FPP/GPP) synthase family.¹ It is composed of a single helical domain with a large central pocket that contains the active site.² FPPS functions as a homodimer and catalyzes the sequential condensation of dimethylallyl pyrophosphate (DMAPP) to C15 farnesyl pyrophosphate, which is necessary for the biosynthesis of isoprenoids, sterols, and prenylated proteins.^1,3 A shorter isoform of FPPS lacks the N-terminal mitochondrial targeting peptide and localizes to the cytoplasm and, to a lesser extent, in lysosomes.¹ Increased levels of mRNA encoding FPPS in the frontal cortex are associated with higher levels of phosphorylated tau and earlier disease onset in patients with Alzheimer's disease.⁴ Cayman's FPPS Short Isoform (human, recombinant) protein consists of 368 amino acids and has a calculated molecular weight of 42.4 kDa.

WARNING This product is not for human or veterinary use.

1. Dhar, M.K., Koul, A., and Kaul, S. Farnesyl pyrophosphate synthase: A key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development. N. Biotechnol. 30(2), 114-123 (2013).

2. Kavanagh, K.L., Guo, K., Dunford, J.E., et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc. Natl. Acad. Sci. U S A 103(20), 7829-7834 (2006).

3. Dunford, J.E., Kwaasi, A.A., Rogers, M.J., et al. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase. J. Med. Chem. 51(7), 2187-2195 (2008).

4. Pelleieux, S., Picard, C., Lamarre-Théroux, L., et al. Isoprenoids and tau pathology in sporadic Alzheimer’s disease. Neurobiol. Aging 65, (2018).