An inhibitor of the dengue virus NS3-NS4B protein-protein interaction
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JNJ-A07

Item No. 43714

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(+)-4-[3-[[1-(4-chlorophenyl)-2-[2,3-dihydro-6-(trifluoromethoxy)-1H-indol-1-yl]-2-oxoethyl]amino]-5-methoxyphenoxy]-butanoic acid
CAS Number
2135640-93-4
Molecular Formula
C28H26ClF3N2O6
Formula Weight
579.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N1C2=CC(OC(F)(F)F)=CC=C2CC1)C(NC3=CC(OCCCC(O)=O)=CC(OC)=C3)C4=CC=C(Cl)C=C4
InChi Code
InChI=1S/C28H26ClF3N2O6/c1-38-22-13-20(14-23(15-22)39-12-2-3-25(35)36)33-26(18-4-7-19(29)8-5-18)27(37)34-11-10-17-6-9-21(16-24(17)34)40-28(30,31)32/h4-9,13-16,26,33H,2-3,10-12H2,1H3,(H,35,36)
InChi Key
WUBVXTOLZKVNEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    JNJ-A07 is an inhibitor of the protein-protein interaction between dengue virus non-structural protein 3 (NS3) and NS4B (EC50 = 35 nM in a pull-down assay).1 It inhibits replication of 21 dengue virus clinical isolates in Vero E6 cells (EC50s = 0.07-0.3 nM). JNJ-A07 reduces dengue virus RNA levels in mosquitos (A. aegypti) when fed blood meals containing it at a concentration of at 2 µM.2 It decreases blood dengue virus RNA levels and increases survival in a mouse model of dengue virus infection when administered at doses of 1, 3, 10, or 30 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaptein, S.J.F., Goethals, O., Kiemel, D., et al. A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. Nature 597(7881), 504-509 (2021).

    2. Rosales-Rosas, A.L., Goossens, S., Chiu, W., et al. The antiviral JNJ-A07 significantly reduces dengue virus transmission by Aedes aegypti mosquitoes when delivered via blood-feeding. Sci. Adv. 10(48), eadr8338 (2024).