A CK1α degrader
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Proteolysis
Ubiquitin/Proteasome System

TMX-4116

Item No. 43720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-[4-methoxy-5-(1-pyrrolidinylcarbonyl)-3-thienyl]-1H-1,2,3-triazol-1-yl]-2,6-piperidinedione
CAS Number
2766385-56-0
Molecular Formula
C17H19N5O4S
Formula Weight
389.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥10 mg/ml
SMILES
COC1=C(SC=C1C2=CN(N=N2)C(C(N3)=O)CCC3=O)C(N4CCCC4)=O
InChi Code
InChI=1S/C17H19N5O4S/c1-26-14-10(9-27-15(14)17(25)21-6-2-3-7-21)11-8-22(20-19-11)12-4-5-13(23)18-16(12)24/h8-9,12H,2-7H2,1H3,(H,18,23,24)
InChi Key
OOIINFBRWZQRRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $98

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    5 mg

    $466

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    10 mg

    $784

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    25 mg

    $1,591

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    Product Description

    TMX-4116 is a casein kinase 1α (CK1α) degrader.1 It selectively induces E3 ubiquitin ligase-mediated degradation of CK1α over phosphodiesterase 6D (PDE6D), Ikaros family zinc finger protein 1 (IKZF1), and IKZF3 in MM.1S cells when used at concentrations ranging from 0.04 to 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Teng, M., Lu, W., Donovan, K.A., et al. Development of PDE6D and CK1α degraders through chemical derivatization of FPFT-2216. J. Med. Chem. 65(1), 747-756 (2022).