An irreversible inhibitor of LSD1
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

IMG-7289 (tosylate)

Item No. 43733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-4-[[(1R ,2S)-2-(4-fluorophenyl)cyclopropyl]amino]-1-[(4-methyl-1-piperazinyl)carbonyl]butyl]-4-(1H-1,2,3-triazol-1-yl)-benzamide, 4-methylbenzenesulfonate (1:2)
CAS Number
1990504-72-7
Synonyms
  • Bomedemstat ditosylate
Molecular Formula
C28H34FN7O2 • 2C7H8O3S
Formula Weight
864.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(N2CCN(CC2)C)[C@@H](NC(C3=CC=C(N4C=CN=N4)C=C3)=O)CCCN[C@H]5[C@H](C6=CC=C(C=C6)F)C5.O=S(O)(C7=CC=C(C=C7)C)=O
InChi Code
InChI=1S/C28H34FN7O2.2C7H8O3S/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36;2*1-6-2-4-7(5-3-6)11(8,9)10/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37);2*2-5H,1H3,(H,8,9,10)/t24-,25-,26+;;/m0../s1
InChi Key
WLRWBXFBIJMKHG-DVNXTAPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $75

    Add

    5 mg

    $206

    Add

    10 mg

    $374

    Add

    25 mg

    $655

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    IMG-7289 is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1).1 It induces cell cycle arrest at the S phase in SET-2 acute megakaryoblastic leukemia cells and apoptosis in Ba/F3 murine hematopoietic cells expressing Jak2 containing a valine-to-phenylalanine substitution at position 617 (Jak2V617F) when used at a concentration of 1 µM. IMG-7289 (45 mg/kg per day) decreases blood levels of leukocytes, neutrophils, monocytes, and platelets, increases bone marrow cell levels of trimethylated lysine 4 histone 3 (H3K4me3) and H3K9me2, decreases spleen fibrosis and weight, and increases survival in a Jak2V617F mouse model of myelofibrosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jutzi, J.S., Kleppe, M., Dias, J., et al. LSD1 inhibition prolongs survival in mouse models of MPN by selectively targeting the disease clone. Hemasphere 2(3), e54 (2018).