An ionizable cationic lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

YK-712

Item No. 43736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[[5-(2-decyl-1,3-dioxolan-4-yl)pentyl](2-hydroxyethyl)amino]-octanoic acid, 1-octylnonyl ester
CAS Number
2965384-81-8
Molecular Formula
C45H89NO5
Formula Weight
724.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥ 10 mg/ml
SMILES
O=C(CCCCCCCN(CCO)CCCCCC1OC(CCCCCCCCCC)OC1)OC(CCCCCCCC)CCCCCCCC
InChi Code
InChI=1S/C45H89NO5/c1-4-7-10-13-16-17-22-29-36-45-49-41-43(51-45)34-27-24-31-38-46(39-40-47)37-30-23-18-21-28-35-44(48)50-42(32-25-19-14-11-8-5-2)33-26-20-15-12-9-6-3/h42-43,45,47H,4-41H2,1-3H3
InChi Key
BZWQIBPYHDAROS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $85

    Add

    5 mg

    $319

    Add

    10 mg

    $595

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    YK-712 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 Intramuscular administration of LNPs containing YK-712 and encapsulating mRNA encoding luciferase accumulate primarily in the liver in mice, while those containing both YK-712 and an adjuvant lipid, YK-TLR-001, which contains the toll-like receptor 7/8 (TLR7/8) dual agonist AXC-715 (YK-712-TLR-LNPs), accumulate primarily in the spleen. Intramuscular administration of YK-712-TLR-LNPs encapsulating mRNA encoding ovalbumin (OVA) promotes the maturation of antigen-presenting cells (APCs), induces activation of T cells, and increases plasma levels of IFN-γ in mice. Intramuscular administration of YK-712-TLR-LNPs also reduces tumor growth and increases survival in a murine model of melanoma using OVA-expressing B16/F10 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H., Y., Z., J., M., et al. Cyclic acetal-based lipid nanoparticles deliver mRNA in vivo for tumor immunotherapy. ACS Appl. Bio. Mater. 8(5), 3888-3898 (2025).