A ferroptosis inducer
Related Products
Enantiomer(s)
44421GPX4 (S)-9i
Isomer(s)
43114GPX4 9i
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GPX4 (R)-9i

Item No. 43737

Product Insert (PDF)
Technical Information
Formal Name
(R)-N-(1-(benzo[b]thiophen-3-yl)-2-(tert-butylamino)-2-oxoethyl)-2-ethynyl-N-(4-(oxazol-5-yl)phenyl)thiazole-4-carboxamide
Synonyms
  • Glutathione Peroxidase 4 (R)-9i
Molecular Formula
C29H24N4O3S2
Formula Weight
540.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(C)(C)NC([C@@H](C1=CSC2=CC=CC=C21)N(C3=CC=C(C=C3)C4=CN=CO4)C(C5=CSC(C#C)=N5)=O)=O
InChi Code
InChI=1S/C29H24N4O3S2/c1-5-25-31-22(16-38-25)28(35)33(19-12-10-18(11-13-19)23-14-30-17-36-23)26(27(34)32-29(2,3)4)21-15-37-24-9-7-6-8-20(21)24/h1,6-17,26H,2-4H3,(H,32,34)/t26-/m1/s1
InChi Key
NBLAYHIFDLIFHK-AREMUKBSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    GPX4 (R)-9i is a ferroptosis inducer.1 It binds to GPX4 in a cellular thermal shift assay (CETSA) using HT-1080 fibrosarcoma cells (Kd = 20.4 nM) and inhibits GPX4 activity in a cell-free assay. It is cytotoxic to HT-1080 cells, an effect that can be reversed by the ferroptosis inhibitor ferrostatin-1 (IC50s = 0.3 and 7,482 nM, respectively). The cytotoxicity of GPX4 (R)-9i to HT-1080 cells is not reversed by the addition of Z-VAD-FMK, indicating selectivity for ferroptosis over apoptosis. It is also cytotoxic to HepG2 hepatocellular carcinoma, MCF-7 breast cancer, CAL 27 oral cancer, and 4T1 murine mammary cancer cells (IC50s = 56, 452, 2,682, and 89 nM, respectively). GPX4 (R)-9i (15 and 30 mg/kg) reduces tumor growth in an HT-1080 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, S., Yang, G., Bian, H., et al. Development of a highly selective ferroptosis inducer targeting GPX4 with 2-ethynylthiazole-4-carboxamide as electrophilic warhead. J. Med. Chem. 68(3), 3309-3323 (2025).