Citrullinated BSA

Citrulline is a non-proteinogenic amino acid that is produced by deimination of arginine through the post-translational modification citrullination.¹ Citrullination is catalyzed by protein arginine deiminases (PADs) that convert positively charged arginine to electrically neutral citrulline, decreasing the isoelectric point of the protein, altering the native protein structure, and influencing protein ionic interactions.² Protein citrullination has roles in many physiological and pathological processes, including autoimmunity, cancer, and neurodegenerative disorders.³ This product contains PAD4-citrullinated bovine serum albumin (BSA), which contains a higher ratio of citrullination than native BSA.

WARNING This product is not for human or veterinary use.

1. Yuzhalin, A.E. Citrullination in cancer. Cancer Res. 79(7), 1274-1284 (2019).

2. György, B., Tóth, E., Falus, A., et al. Citrullination: A posttranslational modification in health and disease. Int. J. Biochem. Cell Biol. 38(10), 1662-1677 (2006).

3. Lee, C.-Y., Wang, D., Wilhelm, M., et al. Mining the human tissue proteome for protein citrullination. Mol. Cell Proteomics 17(7), 1378-1391 (2018).