For immunochemical detection of BCMA
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BCMA/CD269 Polyclonal Antibody

Item No. 43761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • B cell Maturation Antigen
  • B cell Maturation Protein
  • BCMP
  • TNF Receptor Superfamily Member 17
  • TNFRSF17
Immunogen
Recombinant human BCMA
Formulation (Request formulation change)
20 or 100 µl of protein A-affinity purified polyclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) BCMA
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    20 µl

    $65

    Add

    100 µl

    $293

    Add
    Cayman Chemical
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    Product Description

    B cell maturation antigen (BCMA), also known as CD269, is a member of the TNF receptor superfamily.1 It is composed of an extracellular domain, a transmembrane region, and a cytoplasmic domain.1,2 BCMA is found in the cell membrane of late memory B cells and recognizes TNF superfamily member 13B (TNFSF13B), also known as B cell activating factor (BAFF), and a proliferation-inducing ligand (APRIL), which both promote B cell survival and differentiation into short- or long-lived plasma cells, antibody production, and immunoglobulin class switching.1,3 The extracellular domain of BCMA can cleaved by γ-secretase to release soluble BCMA (sBCMA), which can bind APRIL and prevent APRIL-induced signaling in B cells, reducing B cell survival.2 Increased sBCMA levels are associated with lower progression-free- and overall survival in patients with multiple myeloma.4 Cayman's BCMA/CD269 Polyclonal Antibody can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, S.-F., Anderson, K.C., and Tai, Y.-T. Targeting B cell maturation antigen (BCMA) in multiple myeloma: Potential uses of BCMA-based immunotherapy. Front. Immunol. 9, 1821 (2018).

    2. Laurent, S.A., Hoffmann, F.S., Kuhn, P.-H., et al. γ-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat. Commun. 6, 7333 (2015).

    3. Stohl, W. Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr. Metab. Immune Disord. Drug Targets 6(4), 351-358 (2006).

    4. Ghermezi, M., Li, M., Vardanyan, S., et al. Serum B-cell maturation antigen: A novel biomarker to predict outcomes for multiple myeloma patients. Haematologica 102(4), 785-795 (2017).