SKF 97541

SKF 97541 is a GABA_B receptor agonist.¹ It reduces forskolin-induced cAMP accumulation in rat cortical slices when used at concentrations of 30 and 100 µM.² SKF 97541 reduces excitatory postsynaptic potentials (EPSPs) induced by bicuculline (Item No. 11727) in rat striatal slices (EC₅₀ = 0.092 µM), an effect that can be blocked by CGP 35348 (Item No. 18599).³ It also hyperpolarizes neurons in the substantia nigra in rat brain slices (EC₅₀ = 0.15 µM). SKF 19541 (0.01 and 0.05 mg/kg) reduces the time spent immobile in the forced swim test in rats without reducing basal locomotor activity.⁴

WARNING This product is not for human or veterinary use.

1. Froestl, W., Mickel, S.J., von Sprecher, G., et al. Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J. Med. Chem. 38(17), 3313-3331 (1995).

2. Wierońska, J.M., Kłeczek, N., Woźniak, M., et al. mGlu5-GABAB interplay in animal models of positive, negative and cognitive symptoms of schizophrenia. Neurochem. Int. 88, 97-109 (2015).

3. Seabrook, G.R., Howson, W., and Lacey, M.G. Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. Br. J. Pharmacol. 101(4), 949-957 (1990).

4. Frankowska, M., Filip, M., and Przegaliński, E. Effects of GABAB receptor ligands in animal tests of depression and anxiety. Pharmacol. Rep. 59(6), 645-655 (2007).