An internal standard for the quantification of 1-methylhistamine
Related Products
Unlabeled Version(s)
195161-Methylhistamine (hydrochloride)
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1-Methylhistamine-d3 (hydrochloride)

Item No. 43797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(methyl-d3)-1H-imidazole-4-ethanamine, dihydrochloride
CAS Number
344299-49-6
Synonyms
  • N1-Methylhistamine-d3
  • Ntau-Methylhistamine
  • tele-Methylhistamine-d3
Molecular Formula
C6H8D3N3 • 2HCl
Formula Weight
201.1
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20mg/mlEthanol: 1mg/mlPBS(pH 7.2): 10mg/ml
SMILES
NCCC1=CN(C([2H])([2H])[2H])C=N1.Cl.Cl
InChi Code
InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H/i1D3;;
InChi Key
AGXVEALMQHTMSW-GXXYEPOPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

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    Product Description

    1-Methylhistamine-d3 is intended for use as an internal standard for the quantification of 1-methylhistamine (Item No. 19516) by GC- or LC-MS. 1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism.1 It has been used as a biomarker of brain histaminergic system activity via cerebrospinal fluid (CSF) levels in Alzheimer’s disease patients, as well as those with hypersomnia or other neurological conditions.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lindell, S.E., and Schayer, R.W. Metabolism of injected [14C] histamine in the kidney of the dog. Br. J. Pharmacol. Chemother. 13(1), 52-53 (1958).

    2. Motawaj, M., Peoc'h, K., Callebert, J., et al. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease. J. Alzheimers Dis. 22(3), 861-871 (2010).

    3. Dauvilliers, Y., Delallée, N., Jaussent, I., et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep 35(10), 1359-1366 (2016).