An internal standard for the quantification of dexmedetomidine
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Unlabeled Version(s)
39544Dexmedetomidine
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Dexmedetomidine-d3 (tartrate)

Item No. 43801

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1S)-1-(2,3-dimethylphenyl)ethyl-2,2,2-d3]-1H-imidazole, 2R,3R-dihydroxybutanedioate
Synonyms
  • MPV 1440-d3
Molecular Formula
C13H13D3N2 • C4H6O6
Formula Weight
353.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleWater: Slightly soluble
SMILES
CC1=C(C)C([C@H](C([2H])([2H])[2H])C2=CN=CN2)=CC=C1.O=C(O)[C@H](O)[C@@H](O)C(O)=O
InChi Code
InChI=1S/C13H16N2.C4H6O6/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;5-1(3(7)8)2(6)4(9)10/h4-8,11H,1-3H3,(H,14,15);1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1/i3D3;
InChi Key
ITWNPJSUZOQVNY-BITIEFMISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dexmedetomidine-d3 is intended for use as an internal standard for the quantification of dexmedetomidine (Item No. 39544) by GC- or LC-MS. Dexmedetomidine is an agonist of α2-adrenergic receptors (α2-ARs).1 It selectively binds to α2-ARs over α1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial apoptosis, pyroptosis, and ferroptosis in a mouse model of sepsis induced by cecal ligation and puncture (CLP), effects that can be reversed by the α2-AR antagonist yohimbine (Item No. 19869).2 Dexmedetomidine (40 µg/kg) induces sedation and decreases mechanical nociception in cats.3 Formulations containing dexmedetomidine have been used as sedatives.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, T.M., Jetter, M.C., McDonnell, M.E., et al. α2 Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J. Med. Chem. 43(7), 1423-1426 (2000).

    2. Wang, C., Yuan, W., Hu, A., et al. Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury. Mol. Med. Rep. 22(1), 175-184 (2020).

    3. Nagore, L., Soler, C., Gil, L., et al. Sedative effects of dexmedetomidine, dexmedetomidine-pethidine and dexmedetomidine-butorphanol in cats. J. Vet. Pharmacol. Ther. 6(3), 222-228 (2013).