An ionizable cationic lipidoid
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DMA4-H228

Item No. 43807

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((3,3'-((2-(1-methylpyrrolidin-2-yl)ethyl)azanediyl)bis(propanoyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-(dioctylamino)-4-oxobutanoate)
CAS Number
3091917-64-2
Molecular Formula
C57H106N4O10
Formula Weight
1007.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCN(C(CCC(OCCOC(CCN(CCC1N(C)CCC1)CCC(OCCOC(CCC(N(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O)=O)=O)CCCCCCCC
InChi Code
InChI=1S/C57H106N4O10/c1-6-10-14-18-22-26-40-60(41-27-23-19-15-11-7-2)52(62)32-34-54(64)68-47-49-70-56(66)37-45-59(44-36-51-31-30-39-58(51)5)46-38-57(67)71-50-48-69-55(65)35-33-53(63)61(42-28-24-20-16-12-8-3)43-29-25-21-17-13-9-4/h51H,6-50H2,1-5H3
InChi Key
OPRKPOFEXCTWIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing DMA4-H228 selectively accumulate in antigen-presenting cells in the spleen in mice. DMA4-H228-containing LNPs encapsulating mRNA encoding ovalbumin induce activation of splenic antigen-presenting cells and increase serum levels of IFN-α in mice. LNPs containing DMA4-H228 and encapsulating mRNA encoding ovalbumin decrease tumor volume and increase intratumoral CD8+ T cells and serum anti-ovalbumin IgG titers in a B16/F10-OVA murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, X., Zhang, C., Yin, Q., et al. Dimethylamino-based synthetic lipidoid nanoparticles for selective mRNA delivery to splenic antigen-presenting cells. J. Control Release 382, 113737 (2025).