A CRY2 stabilizer
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Thermogenesis

TH301

Item No. 43814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]-cyclopentanecarboxamide
CAS Number
450338-32-6
Molecular Formula
C24H24ClN3O4S
Formula Weight
486.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(C1(CCCC1)C2=CC=C(C=C2)Cl)NC3=C4C(CS(=O)(C4)=O)=NN3C5=CC=C(C=C5)OC
InChi Code
InChI=1S/C24H24ClN3O4S/c1-32-19-10-8-18(9-11-19)28-22(20-14-33(30,31)15-21(20)27-28)26-23(29)24(12-2-3-13-24)16-4-6-17(25)7-5-16/h4-11H,2-3,12-15H2,1H3,(H,26,29)
InChi Key
DDCUCVXSGYHWRJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $168

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    10 mg

    $317

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    Product Description

    TH301 is a stabilizer of cryptochrome circadian regulator 2 (CRY2).1 It selectively stabilizes CRY2 over CRY1 in a degradation assay using HEK293 cells expressing CRY reporters at 0.1 to 10 µM. TH301 lengthens the circadian period in wild-type but not Cry2-/- mouse fibroblasts. It enhances rosiglitazone-dependent upregulation of the brown adipose tissue-specific genes Ucp1, Cidea, and Kcnk3 in primary mouse stromal vascular fractions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, S., Son, Y.L., Aikawa, Y., et al. Isoform-selective regulation of mammalian cryptochromes. Nat. Chem. Biol. 16(6), 676-685 (2020).