A peptide fragment of ACTH
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ACTH (4-9) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 43819

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophan, trifluoroacetate salt
Synonyms
  • Adrenocorticotropic Hormone (4-9)
  • Corticotropin (4-9)
Molecular Formula
C42H56N12O9S • XCF3COOH
Formula Weight
905.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
[H]N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C42H56N12O9S.C2HF3O2/c1-64-17-15-28(43)36(57)50-31(13-14-35(55)56)38(59)53-33(20-26-22-46-23-49-26)40(61)52-32(18-24-8-3-2-4-9-24)39(60)51-30(12-7-16-47-42(44)45)37(58)54-34(41(62)63)19-25-21-48-29-11-6-5-10-27(25)29;3-2(4,5)1(6)7/h2-6,8-11,21-23,28,30-34,48H,7,12-20,43H2,1H3,(H,46,49)(H,50,57)(H,51,60)(H,52,61)(H,53,59)(H,54,58)(H,55,56)(H,62,63)(H4,44,45,47);(H,6,7)/t28-,30-,31-,32-,33-,34-;/m0./s1
InChi Key
LINOGYJLAVAUKT-ZNRQHCRPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $273

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    10 mg

    $478

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    Product Description

    Adrenocorticotropic hormone (ACTH) (4-9) is a peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1 The amino acid sequence of ACTH (4-9) is common to ACTH and α- and β-melanocyte stimulating hormones.2 ACTH (4-9) (50 µg/kg) reduces neuronal damage induced by dexamethasone (Item No. 11015) in mouse hippocampal pyramidal neurons.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lightman, S.L., Birnie, M.T., and Conway-Campbell, B.L. Dynamics of ACTH and cortisol secretion and implications for disease. Endocr. Rev. 41(3), 470-490 (2020).

    2. Miwa, H., Gantz, I., Konda, Y., et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J. Pharmacol. Exp. Ther. 273(1), 367-372 (1995).

    3. Sekita-Krzak, J., Zebrowska-Lupina, I., Czerny, K., et al. Neuroprotective effect of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: Morphological, immunocytochemical and ultrastructural studies. Acta Neurobiol. Exp. (Wars.) 63(1), 1-8 (2003).