An isocoumarin with anti-angiogenic activity
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6-Methoxy-8-hydroxyisocoumarin-3-carboxylic Acid

Item No. 43835

Product Insert (PDF)
Technical Information
Formal Name
8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-carboxylic acid
CAS Number
39051-96-2
Molecular Formula
C11H8O6
Formula Weight
236.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C(O1)=CC2=C(C(O)=CC(OC)=C2)C1=O)O
InChi Code
InChI=1S/C11H8O6/c1-16-6-2-5-3-8(10(13)14)17-11(15)9(5)7(12)4-6/h2-4,12H,1H3,(H,13,14)
InChi Key
LMYWVTVHSMUDIN-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $578

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    Product Description

    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid is an isocoumarin that has been found in A. ochraceus and has anti-angiogenic activity.1,2 It inhibits Sarcoma 180 cell-induced angiogenesis in an implanted dorsal air sac in mice when administered at a dose of 100 mg/kg per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamazaki, M., Maebayashi, Y., and Miyaki, K. Isolation of a new metabolite, 6-methoxy-8-hydroxyisocoumarin-3-carboxylic acid from Aspergillus ochraceus Wilh. Chem. Pharm. Bull. 20(10), 2276-2278 (1972).

    2. Matsumoto, N., Nakashima, T., Isshiki, K., et al. Synthesis and biological evaluation of cytogenin derivatives. J. Antibiot. (Tokyo) 54(3), 285-296 (2001).