A quinone with enzyme inhibitory and anti-inflammatory activities
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Pronqodine A

Item No. 43836

Product Insert (PDF)
Technical Information
Formal Name
5-(methylamino)-1,2-benzisothiazole-4,7-dione
CAS Number
1424195-39-0
Molecular Formula
C8H6N2O2S
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1C=C(C(C2=C1SN=C2)=O)NC
InChi Code
InChI=1S/C8H6N2O2S/c1-9-5-2-6(11)8-4(7(5)12)3-10-13-8/h2-3,9H,1H3
InChi Key
FIAXOEDOQLZQMW-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp. MK832-95F2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $578

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    Product Description

    Pronqodine A is a quinone that has been found in Streptomyces and has enzyme inhibitory and anti-inflammatory activities.1,2 It inhibits NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = 131.5 nM).2 Pronqodine A inhibits bradykinin-induced prostaglandin E2 (PGE2; Item No. 14010), 6-keto PGF1α (Item No. 15210), and PGD2 (Item No. 12010) production in SW 982 human synovial sarcoma cells (IC50s = 9, 19, and 7 nM, respectively).1 It also induces the production of reactive oxygen species (ROS) in SW 982 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakae, K., Adachi, H., Sawa, R., et al. NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. J. Nat. Prod. 76(4), 510-515 (2013).

    2. Blunt, C.E., Torcuk, C., Liu, Y., et al. Synthesis and intracellular redox cycling of natural quinones and their analogues and identification of indoleamine-2,3-dioxygenase (IDO) as potential target for anticancer activity. Angew. Chem. Int. Ed. Engl. 54(30), 8740-8745 (2015).