An ionizable cationic lipid
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nor-MC3

Item No. 43859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9Z,12Z)-1-(8Z,11Z)-8,11-heptade butanoic acid, 4-(dimethylamino)-cadien-1-yl-9,12-octadecadien-1-yl ester
CAS Number
2870681-06-2
Molecular Formula
C41H75NO2
Formula Weight
614.1
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥ 10 mg/ml
SMILES
O=C(OC(CCCCCCC/C=C\C/C=C\CCCCC)CCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C
InChi Code
InChI=1S/C41H75NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-40(44-41(43)38-35-39-42(3)4)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,40H,5-12,17-18,23-39H2,1-4H3/b15-13-,16-14-,21-19-,22-20-
InChi Key
FJHKZFSVYMUJKI-KWXKLSQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $88

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    10 mg

    $141

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    25 mg

    $308

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    50 mg

    $528

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    Product Description

    nor-MC3 is an ionizable cationic lipid that has been used in the generation of liposomal lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo and is a derivative of DLin-MC3-DMA (Item No. 34364).1 Liposomal LNPs containing nor-MC3 at a molar ratio of 20:40:40:1.5 for nor-MC3:egg sphingomyelin:cholesterol:DMG-PEG(2000) compared with those with a molar ratio of 50:10:38.5:1.5 exhibit higher transfection efficiencies in vitro. Liposomal LNPs containing nor-MC3 at a molar ratio of 20:40:40:1.5 accumulate in the spleen, pancreas, heart, kidney, muscle, and inguinal lymph nodes in mice to a greater extent than those with a molar ratio of 50:10:38.5:1.5.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, H.Y., Zhang, Y., Fox, K., et al. Liposomal lipid nanoparticles for extrahepatic delivery of mRNA. Nat. Commun. 16(1), (2025).