A cyclen-based ionizable cationic lipidoid
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Lipid OEs-K

Item No. 43862

Product Insert (PDF)
Technical Information
Formal Name
(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(2-hydroxypropane-3,1-diyl)tetrakis(2-hexyldecanoate)
Synonyms
  • Lipidoid OEs-K
  • OEs-K
Molecular Formula
C84H164N4O12
Formula Weight
1422.2
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform:Methanol (2:1): Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
OC(COC(C(CCCCCC)CCCCCCCC)=O)CN1CCN(CC(O)COC(C(CCCCCC)CCCCCCCC)=O)CCN(CC(O)COC(C(CCCCCC)CCCCCCCC)=O)CCN(CC(COC(C(CCCCCCCC)CCCCCC)=O)O)CC1
InChi Code
InChI=1S/C84H164N4O12/c1-9-17-25-33-37-45-53-73(49-41-29-21-13-5)81(93)97-69-77(89)65-85-57-59-86(66-78(90)70-98-82(94)74(50-42-30-22-14-6)54-46-38-34-26-18-10-2)61-63-88(68-80(92)72-100-84(96)76(52-44-32-24-16-8)56-48-40-36-28-20-12-4)64-62-87(60-58-85)67-79(91)71-99-83(95)75(51-43-31-23-15-7)55-47-39-35-27-19-11-3/h73-80,89-92H,9-72H2,1-8H3
InChi Key
IEWGHGMQGDIYRJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    5 mg

    $319

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    10 mg

    $595

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    Cayman Chemical
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    Product Description

    Lipid OEs-K is a cyclen-based ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing lipid OEs-K accumulate in the lymph nodes of mice. LNPs containing lipid OEs-K and encapsulating ovalbumin (OVA) mRNA increase the uptake of dendritic cells by the lymph nodes and inhibit tumor growth in a murine E.G7-OVA model of lymphoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L., Chen, P., Tian, X.-L., et al. Cyclen-based lipidoids for mRNA delivery and immunotherapy. Biomater. Sci. 13(10), 2783-2793 (2025).