A starting material
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Cyclen

Item No. 43902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4,7,10-tetraazacyclododecane
CAS Number
294-90-6
Synonyms
  • NSC 629374
  • Tetraaza-12-Crown-4
Molecular Formula
C8H20N4
Formula Weight
172.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Sparingly soluble: 1-10 mg/ml
SMILES
N1CCNCCNCCNCC1
InChi Code
InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
InChi Key
QBPPRVHXOZRESW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $54

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    25 g

    $128

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    50 g

    $175

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    100 g

    $244

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    Product Description

    Cyclen is a starting material.1 It has been used in the synthesis of cationic lipids for the generation of lipid nanoparticles (LNPs), sodium-, potassium-, rubidium-, and cesium-chelating tetraazamacrocyclic compounds, and zinc- and cadmium-specific fluorescent probes.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Q.-D., Zhong, G.-X., Zhang, Y., et al. Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells. PLoS One 6(8), e23134 (2011).

    2. Delgado, R., Siegfried, L.C., and Kaden, T.A. Protonation studies and complexation properties of tetraazamacrocyclic methylenephosphonates with earth-alkali Ions. Helvetica Chimica Acta 73, 140-148 (1990).

    3. Shiraishi, Y., Kohno, Y., and Hirai, T. Fluorometric detection of pH and metal cations by 1,4,7,10-tetraazacyclododecane (cyclen) bearing two anthrylmethyl groups. Ind. Eng. chem. Res. 44, 847-851 (2005).