An internal standard for the quantification of dimethyl sulfone
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Dimethyl sulfone-d6

Item No. 43909

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
sulfonylbis-methane-d3
CAS Number
22230-82-6
Synonyms
  • DMSO2-d6
  • Methylsulfonylmethane-d6
  • MSM-d6
Molecular Formula
C2D6O2S
Formula Weight
100.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
[2H]C([2H])(S(=O)(C([2H])([2H])[2H])=O)[2H]
InChi Code
InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3/i1D3,2D3
InChi Key
HHVIBTZHLRERCL-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    100 mg

    $528

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    Product Description

    Dimethyl sulfone-d6 is intended for use as an internal standard for the quantification of dimethyl sulfone by GC- or LC-MS. Dimethyl sulfone is a naturally occurring organosulfur compound.1,2 It has been found in O. indicum, human plasma, urine, and cerebrospinal fluid (CSF), and bovine milk. Dimethyl sulfone inhibits the proliferation of primary bovine aortic smooth muscle cells and endothelial cells in a concentration-dependent manner.3 It decreases total arthritic scores and articular cartilage structural damage in a mouse model of spontaneous osteoarthritis when administered at a dose of 0.6 g/kg per day in the diet.4 Dimethyl sulfone has been used as a high-temperature, polar, aprotic solvent and as an electrolyte in lithium ion batteries.5,6 Formulations containing dimethyl sulfone have been used as dietary supplements, food additives, and moisturizers in cosmetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, R.Y., Cao, Y.Y., Chen, C.Y., et al. Antioxidant flavonoids from the seed of Oroxylum indicum. Fitoterapia 82(6), 841-848 (2011).

    2. He, X., and Slupsky, C.M. Metabolic fingerprint of dimethyl sulfone (DMSO2) in microbial-mammalian co-metabolism. J. Proteome Res. 13(12), 5281-5292 (2014).

    3. Layman, D.L. Growth inhibitory effects of dimethyl sulfoxide and dimethyl sulfone on vascular smooth muscle and endothelial cells in vitro. In Vitro Cell. Dev. Biol. 23(6), 422-428 (1987).

    4. Ezaki, J., Hashimoto, M., Hosokawa, Y., et al. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J. Bone Miner. Metab. 31(1), 16-25 (2013).

    5. Clark, T., Murray, J.S., Lane, P., et al. Why are dimethyl sulfoxide and dimethyl sulfone such good solvents? J. Mol. Model 14(8), 689-697 (2008).

    6. Hofmann, A., Migeot, M., Thißen, E., et al. Electrolyte mixtures based on ethylene carbonate and dimethyl sulfone for Li-Ion batteries with improved safety characteristics. ChemSusChem 8(11), 1892-1900 (2015).