A positive allosteric modulator of mGluR5
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

VU29

Item No. 43928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-benzamide
CAS Number
890764-36-0
Molecular Formula
C22H16N4O3
Formula Weight
384.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(C1=CC=C([N+]([O-])=O)C=C1)NC2=CC(C3=CC=CC=C3)=NN2C4=CC=CC=C4
InChi Code
InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27)
InChi Key
KIALCSMRIHRFPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $104

    Add

    10 mg

    $180

    Add

    25 mg

    $413

    Add
    Product Description

    VU29 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5; Ki = 250 nM).1 It potentiates glutamate-induced calcium flux in primary rat cortical astrocytes (EC50 = 10.7 nM). VU29 (30 mg/kg) prevents ethanol-induced memory impairments in the novel object recognition test in rats.2 It also reverses ethanol-induced conditioned place preference in rats when administered at a dose of 10 mg/kg for ten days, an effect that can be reversed by MTEP (Item No. 14961) or MK-801.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Paulis, T., Hemstapat, K., Chen, Y., et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J. Med. Chem. 49(11), 3332-3344 (2006).

    2. Marszalek-Grabska, M., Gibula-Bruzda, E., Bodzon-Kulakowska, A., et al. Effects of the positive allosteric modulator of metabotropic glutamate receptor 5, VU-29, on impairment of novel object recognition induced by acute ethanol and ethanol withdrawal in rats. Neurotox. Res. 33(3), 607-620 (2018).

    3. Marszalek-Grabska, M., Gawel, K., Matosiuk, D., et al. Effects of the positive allosteric modulator of metabotropic glutamate receptor 5, VU-29, on maintenance association between environmental cues and rewarding properties of ethanol in rats. Biomolecules 10(5), 793 (2020).