An HDAC inhibitor
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Nanatinostat

Item No. 43931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1α,5α,6α)-6-[[(6-fluoro-2-quinolinyl)methyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-N-hydroxy-5-pyrimidinecarboxamide
CAS Number
1256448-47-1
Synonyms
  • CHR-3996
Molecular Formula
C20H19FN6O2
Formula Weight
394.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
[H][C@@]12CN(C[C@]([C@H]2NCC(C=C3)=NC4=C3C=C(F)C=C4)1[H])C5=NC=C(C=N5)C(NO)=O
InChi Code
InChI=1S/C20H19FN6O2/c21-13-2-4-17-11(5-13)1-3-14(25-17)8-22-18-15-9-27(10-16(15)18)20-23-6-12(7-24-20)19(28)26-29/h1-7,15-16,18,22,29H,8-10H2,(H,26,28)/t15-,16+,18+
InChi Key
QRGHOAATPOLDPF-VQFNDLOPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $109

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    5 mg

    $436

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    10 mg

    $654

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    25 mg

    $1,226

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    Cayman Chemical
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    Product Description

    Nanatinostat is an inhibitor of histone deacetylases (HDACs).1 It selectively inhibits HDAC1, HDAC2, and HDAC3 over HDAC5 and HDAC6 (IC50s = 3, 4, 7, 200, and 2,100 nM, respectively). Nanatinostat inhibits proliferation in a panel of 15 cancer cell lines (GI50s = 31-750 nM). It induces cell cycle arrest at the sub-G1 and G2/M phases and induces apoptosis in HCT116 colorectal cancer cells when used at a concentration of 3 µM. Nanatinostat (50 mg/kg per day) decreases tumor volume in an HCT116 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moffat, D., Patel, S., Day, F., et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J. Med. Chem. 53(24), 8663-8678 (2010).