A UGM inhibitor
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Rpn-13 Inhibitor TCL1

Item No. 43982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4bromophenyl)methyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine-7-acetic acid
CAS Number
875165-39-2
Synonyms
  • TCL-1
Molecular Formula
C19H14BrClN4O2S
Formula Weight
477.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
BrC1=CC=C(CC2=NN=C(SC3CC(O)=O)N2N=C3C4=CC=C(C=C4)Cl)C=C1
InChi Code
InChI=1S/C19H14BrClN4O2S/c20-13-5-1-11(2-6-13)9-16-22-23-19-25(16)24-18(15(28-19)10-17(26)27)12-3-7-14(21)8-4-12/h1-8,15H,9-10H2,(H,26,27)
InChi Key
BWGPJTANFXCCTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Rpn-13 inhibitor TCL1 is an inhibitor of UDP-galactopyranose mutase (UGM), also known as RfbD (Ki = 1.1 µM for the K. pneumoniae enzyme).1 It also binds to proteasomal ubiquitin receptor ADRM1, also known as proteasome regulatory particle non-ATPase 13 (Rpn-13; Kd = ~26 µM).2 Rpn-13 inhibitor TCL1 decreases growth of M. tuberculosis and M. smegmatis in a disk diffusion assay (MICs = 9.3 and 9.4 µg/ml, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kincaid, V.A., London, N., Wangkanont, K., et al. Virtual screening for UDP-galactopyranose mutase ligands identifies a new class of antimycobacterial agents. ACS Chem. Biol. 10(10), 2209-2218 (2015).

    2. Loy, C.A., Muli, C.S., Ali, E.M.H., et al. Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers. Bioorg. Med. Chem. Lett. 95, 129485 (2023).