An inhibitor of the annexin A2-S100A10 protein-protein interaction
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A2ti-1

Item No. 43993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H1,2,4-triazol-3-yl]thio]-acetamide
CAS Number
570390-00-0
Molecular Formula
C20H22N4O2S
Formula Weight
382.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CCC1=C(C=CC=C1)N2C(COC(C=CC=C3)=C3C)=NN=C2SCC(N)=O
InChi Code
InChI=1S/C20H22N4O2S/c1-3-15-9-5-6-10-16(15)24-19(22-23-20(24)27-13-18(21)25)12-26-17-11-7-4-8-14(17)2/h4-11H,3,12-13H2,1-2H3,(H2,21,25)
InChi Key
KNQGIFUBCFRGDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $242

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    10 mg

    $363

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    25 mg

    $757

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    Product Description

    A2ti-1 is an inhibitor of the protein-protein interaction between annexin A2 and S100A10 (IC50 = 24 µM in a cell-free assay).1 It prevents human papillomavirus 16 (HPV16) infection in HeLa cells when used at concentrations ranging from 25 to 100 µM.2 A2ti-1 (2 and 10 µM) enhances cytotoxicity induced by doxorubicin (Item No. 15007) in Hs 578T triple-negative breast cancer (TNBC) cells.3 It disrupts circadian regulation of intracellular calcium oscillations in primary mouse suprachiasmatic nucleus astrocytes and neurons when used at a concentration of 80 µM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reddy, T.R.K., Li, C., Fischer, P.M., et al. Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction. ChemMedChem 7(8), 1435-1446 (2012).

    2. Woodham, A.W., Taylor, J.R., Jimenez, A.I., et al. Small molecule inhibitors of the annexin A2 heterotetramer prevent human papillomavirus type 16 infection. J. Antimicrob. Chemother. 70(6), 1686-1690 (2015).

    3. Koh, M., Lim, H., Jin, H., et al. ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells. Autophagy 20(3), 659-674 (2024).

    4. Patton, A.P., Krogager, T.P., Maywood, E.S., et al. Multi-omic analysis reveals astrocytic annexin-A2 as critical for network-level circadian timekeeping in the suprachiasmatic nucleus. Glia 73(7), 1483-1501 (2025).