Active • Host: E. coli • AA: 23-354 • Tag: N-terminal His • MW: 38.37 kDa
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ARG2 (human, recombinant)

Item No. 43995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Arginase-2
  • Kidney-type Arginase
  • Type II Arginase
Purity
≥90% estimated by SDS-PAGE
Source
Active recombinant human N-terminal His-tagged ARG2 expressed in E. coli
Amino Acids
23-354
MW
38.37 kDa
Formulation (Request formulation change)
50 mM Tris, pH 8.0, with 150 mM sodium chloride, 0.2 mM manganese chloride, and 5% glycerol
UniProt Accession №
P78540
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $345

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    Product Description

    Arginase-2 (ARG2) is a manganese-metalloenzyme that catalyzes the irreversible hydrolysis of L-arginine (Item No. 23703) into urea and L-ornithine (Item No. 30779).1 It functions as a homotrimer with each subunit containing a binuclear manganese cluster at its active site.2 ARG2 is primarily expressed in kidney, prostate, and brain and localizes to the mitochondria.3,1 It is involved in polyamine synthesis, sexual arousal physiology, and innate and adaptive immunity.4,2,5 Levels of ARG2 are increased in the plasma of patients with erectile dysfunction, in the airway epithelium of patients with asthma, and in the endothelial cells of patients with pulmonary arterial hypertension.6,7 Cayman’s ARG2 (human, recombinant) protein can be used for enzyme activity assay and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moretto, J., Girard, C., and Demougeot, C. The role of arginase in aging: A systematic review. Exp. Gerontol. 116, 54-73 (2019).

    2. Christianson, D.W. Arginase: Structure, mechanism, and physiological role in male and female sexual arousal. Acc. Chem. Res. 38(3), 191-201 (2005).

    3. Vockley, J.G., Jenkinson, C.P., Shukla, H., et al. Cloning and characterization of the human type II arginase gene. Genomics 38(2), 118-123 (1996).

    4. Caldwell, R.W., Rodriguez, P.C., Toque, H.A., et al. Arginase: A multifaceted enzyme important in health and disease. Physiol. Rev. 98(2), 641-665 (2018).

    5. Canè, S., Geiger, R., and Bronte, V. The roles of arginases and arginine in immunity. Nat. Rev. Immunol. 25(4), 266-284 (2025).

    6. Heuser, S.K., Li, J., Pudewell, S., et al. Biochemistry, pharmacology, and in vivo function of arginases. Pharmacol. Rev. 77(1), 100015 (2025).

    7. Xu, W., Kaneko, F.T., Zheng, S., et al. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. The FASEB Journal 18(14), 1746-1748 (2004).