A clickable form of MACTIDE
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MACTIDE Azide

Item No. 43997

Product Insert (PDF)
Technical Information
Formal Name
(6S,9S,12R,15S,18R,23R,26S,28aS,33aS)-18-(2-(6-((S)-3-(4-(2λ4-triaza-1,2-dien-1-yl)phenyl)-2-aminopropanamido)hexanamido)-acetamido)-12-(4-aminobutyl)-6,26-di((S)-sec-butyl)-N-((S)-1-((S)-2-((2-(((S)-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)carbamoyl)pyrrolidin-1-yl)-3-hydroxy-1-oxopropan-2-yl)-15-((R)-1-hydroxyethyl)-9-(hydroxymethyl)-5,8,11,14,17,25,28,33-octaoxooctacosahydro-1H,5H,22H-dipyrrolo[2,1-j:2',1'-m][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosine-23-carboxamide
Synonyms
  • CD206 Cyclic Peptide Ligand Azide
  • UNO-related Cyclic Peptide
Molecular Formula
C77H126N23O20S2
Formula Weight
1758.1
Formulation (Request formulation change)
This vial contains 1 mg of lyophilized peptide trifluoroacetic acid salt.
Peptide Sequence
4-Azido-Phe-(Ahx)-G[CTKSIPPIC]-SPGAK
SMILES
O=C(N[C@H](C(N[C@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N1[C@H](C(N2CCC[C@H]2C3=O)=O)CCC1)=O)[C@H](CC)C)=O)=O)=O)[C@H](O)C)[C@@H](NC(CNC(CCCCCNC([C@H](CC4=CC=C(N=[N]=N)C=C4)N)=O)=O)=O)CSSC[C@H](NC([C@H]([C@H](CC)C)N3)=O)C(N[C@@H](CO)C(N5[C@H](C(NCC(N[C@@H](C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)CCC5)=O)=O
InChi Code
InChI=1S/C77H126N23O20S2/c1-7-42(3)61-73(116)92-54(69(112)91-52(39-102)75(118)98-32-16-21-55(98)71(114)85-37-59(105)86-44(5)65(108)88-49(64(81)107)19-11-13-29-78)41-122-121-40-53(87-60(106)36-84-58(104)24-10-9-15-31-83-66(109)48(80)35-46-25-27-47(28-26-46)96-97-82)70(113)95-63(45(6)103)74(117)89-50(20-12-14-30-79)67(110)90-51(38-101)68(111)94-62(43(4)8-2)77(120)100-34-18-23-57(100)76(119)99-33-17-22-56(99)72(115)93-61/h25-28,42-45,48-57,61-63,82,101-103H,7-24,29-41,78-80H2,1-6H3,(H2,81,107)(H,83,109)(H,84,104)(H,85,114)(H,86,105)(H,87,106)(H,88,108)(H,89,117)(H,90,110)(H,91,112)(H,92,116)(H,93,115)(H,94,111)(H,95,113)/t42-,43-,44-,45+,48-,49-,50+,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1
InChi Key
VAMMLBKBEJRYSA-XTGYZAKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $220

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    Product Description

    MACTIDE azide is a clickable form of MACTIDE, a cyclic peptide that binds CD206 on tumor-associated macrophages (TAMs).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lepland, A., Peranzoni, E., Haljasorg, U., et al. Peptide-drug conjugate for therapeutic reprogramming of tumor-associated macrophages in breast cancer. Adv. Sci. (Weinh) 12(10), e2410288 (2025).