A dual agonist of TLR7 and TLR8
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AXC-715 (hydrochloride)

Item No. 44007

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-2-butyl-1H-imidazo[4,5-c]quinoline-1-butanamine, trihydrochloride
CAS Number
2479276-17-8
Synonyms
  • T785
Molecular Formula
C18H25N5 • 3HCl
Formula Weight
420.8
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl
InChi Code
InChI=1S/C18H25N5.3ClH/c1-2-3-10-15-22-16-17(23(15)12-7-6-11-19)13-8-4-5-9-14(13)21-18(16)20;;;/h4-5,8-9H,2-3,6-7,10-12,19H2,1H3,(H2,20,21);3*1H
InChi Key
ZSUHKPUPLPQJGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $409

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    10 mg

    $654

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    Cayman Chemical
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    Product Description

    AXC-715 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8.1 It activates NF-κB in a secreted alkaline phosphatase (SEAP) assay using TLR7- or TLR8-expressing HEK293 cells (EC50s = 0.634 and 1.3 µM, respectively). AXC-715 has been linked to the anti-HER2 antibody trastuzumab as an antibody-drug conjugate (ADC). AXC-715 linked to trastuzumab reduces tumor volume in an HCC1954 breast cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ackerman, S.E., Pearson, C.I., Gregorio, J.D., et al. Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity. Nat. Cancer 2(1), 18-33 (2021).