An internal standard for the quantification of 1-methyladenosine
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Unlabeled Version(s)
169371-Methyladenosine
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1-Methyladenosine-d3 (hydriodide)

Item No. 44021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-(methyl-d3)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diol monohydroiodide
Synonyms
  • m1A-d3
  • 1-methyl Ado-d3
Molecular Formula
C11H12D3N5O4 • HI
Formula Weight
412.2
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN(C3=N)C([2H])([2H])[2H])O[C@@H]1CO.I
InChi Code
InChI=1S/C11H15N5O4.HI/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11;/h3-5,7-8,11-12,17-19H,2H2,1H3;1H/t5-,7-,8-,11-;/m1./s1/i1D3;
InChi Key
HRVIETAHBNHGAH-OVZJQFLVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $175

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    5 mg

    $438

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    10 mg

    $788

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    25 mg

    $1,750

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    Cayman Chemical
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    Product Description

    1-Methyladenosine-d3 is intended for use as an internal standard for the quantification of 1-methyladenosine (Item No. 16937) by GC- or LC-MS. 1-Methyladenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases.1,2,3 Urine and serum levels of 1-methyladenosine are elevated in several forms of cancer.4,5,6,7 Urine levels of 1-methyladenosine also increase during active rheumatoid arthritis.8

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Munns, T.W., and Sims, H.F. Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells. The Journal of Biological Chemisty 250(6), 2143-2149 (1975).

    2. Vold, B. Modified nucleosides of Bacillus subtilis transfer ribonucleic acids. J. Bacteriol. 127(1), 258-267 (1976).

    3. Chujo, T., and Suzuki, T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA 18(12), 2269-2276 (2012).

    4. Reynaud, C., Bruno, C., Boullanger, P., et al. Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. Cancer Lett. 255-262 (1991).

    5. Seidel, A., Brunner, S., Seidel, P., et al. Modified nucleosides: An accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. Br. J. Cancer. 94(11), 1726-1733 (2006).

    6. Hsu, W.Y., Chen, C.J., Huang, Y.C., et al. Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. PLoS One 8(12), 1-8 (2013).

    7. Chen, F., Xue, J., Zhou, L., et al. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Anal. Bioanal. Chem. 401(6), 1899-1904 (2011).

    8. Tebib, J.G., Reynaud, C., Cedoz, J.P., et al. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. Br. J. Rheumatol. 36(9), 990-995 (1997).