An immunogenic T cell epitope
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

HTLV-1 Tax (11-19) (trifluoroacetate salt)

Item No. 44035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-leucyl-L-phenylalanylglycyl-L-tyrosyl-L-prolyl-Lvalyl-L-tyrosyl-L-valine, trifluoroacetate salt
Synonyms
  • HTLV-1 Tax-1 (11-19)
  • Human T Cell Leukemia Virus Type 1 Tax (11-19)
  • Human T Lymphotropic Virus Type 1 Tax (11-19)
  • Leu-Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val
Molecular Formula
C56H79N9O12 • XCF3COOH
Formula Weight
1070.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
LLFGYPVYV-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N(CCC1)[C@@H]1C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CC(C=C2)=CC=C2O)=O)=O)[C@@H](NC(CNC([C@@H](NC([C@H](CC(C)C)NC([C@@H](N)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)CC(C=C4)=CC=C4O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C56H79N9O12.C2HF3O2/c1-31(2)25-40(57)49(69)60-41(26-32(3)4)51(71)61-42(27-35-13-10-9-11-14-35)50(70)58-30-46(68)59-44(29-37-18-22-39(67)23-19-37)55(75)65-24-12-15-45(65)53(73)63-47(33(5)6)54(74)62-43(28-36-16-20-38(66)21-17-36)52(72)64-48(34(7)8)56(76)77;3-2(4,5)1(6)7/h9-11,13-14,16-23,31-34,40-45,47-48,66-67H,12,15,24-30,57H2,1-8H3,(H,58,70)(H,59,68)(H,60,69)(H,61,71)(H,62,74)(H,63,73)(H,64,72)(H,76,77);(H,6,7)/t40-,41-,42-,43-,44-,45-,47-,48-;/m0./s1
InChi Key
BCXCIHWSNSVXNF-LYDKTYGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $125

    Add

    10 mg

    $220

    Add

    25 mg

    $482

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Human T cell leukemia virus type 1 (HTLV-1) Tax (11-19) is an immunogenic T cell epitope derived from the HTLV-1 oncoprotein Tax.1,2,3 It binds to HLA-A*0201 in a cell-free assay when used at a concentration of 1 nM.1 Co-culture of HTLV-1 Tax (11-19)-primed isolated human HLA-A2-positive mature dendritic cells with naïve autologous peripheral blood lymphocytes induces IFN-γ production in the CD8+ T cell population.2 HTLV-1 Tax (11-19) has been used to evaluate the role of dendritic cells in the cytotoxic CD8+ T cell response in transgenic mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pereira-Santos, T.A., da Rocha, A.S., Lopes-Ribeiro, Á., et al. Diversity of HLA-A2-restricted and immunodominant epitope repertoire of human T-lymphotropic virus type 1 (HTLV-1) Tax protein: Novel insights among N-terminal, central and C-terminal regions. Biomolecules 13(3), 545 (2023).

    2. Manuel, S.L., Schell, T.D., Acheampong, E., et al. Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: The underlying mechanism of HTLV-1-associated neuroinflammatory disease. J. Leukoc. Biol. 86(5), 1205-1216 (2009).

    3. Sagar, D., Masih, S., Schell, T., et al. In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: Implication for dendritic cell-based anti-HTLV-1 vaccine. Vaccine 32(26), 3274-3284 (2014).