An immunogenic T cell epitope
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Human CMV pp65 (495-503)

Item No. 44036

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine
CAS Number
153045-21-7
Synonyms
  • Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val
  • Human CMV 65 kDa Phosphoprotein (495-503)
  • Human Cytomegalovirus pp65 (495-503)
Molecular Formula
C42H74N10O12S
Formula Weight
943.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
NLVPMVATV-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(C)C)=O)C(C)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)[C@@H](C)O)=O)C)=O)C(C)C)=O)CCSC
InChi Code
InChI=1S/C42H74N10O12S/c1-19(2)17-27(47-35(56)25(43)18-29(44)54)37(58)49-31(21(5)6)41(62)52-15-12-13-28(52)38(59)46-26(14-16-65-11)36(57)48-30(20(3)4)39(60)45-23(9)34(55)51-33(24(10)53)40(61)50-32(22(7)8)42(63)64/h19-28,30-33,53H,12-18,43H2,1-11H3,(H2,44,54)(H,45,60)(H,46,59)(H,47,56)(H,48,57)(H,49,58)(H,50,61)(H,51,55)(H,63,64)/t23-,24+,25-,26-,27-,28-,30-,31-,32-,33-/m0/s1
InChi Key
OLLATZWLQXKRHY-JJURSQSHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Human cytomegalovirus (CMV) pp65 (495-503) is an immunogenic T cell epitope derived from the CMV matrix protein 65 kDa phosphoprotein (pp65).1,2 It binds to HLA-A*0201 in a cell-free assay (IC50 = 90 nM) and induces activation of patient-derived antigen-specific CD8+ T cells.1 Human CMV pp65 (495-503) has been used as an antigen to generate anti-pp65 antibodies with antiviral activity in a mouse model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gibadullin, R., Randall, C.J., Sidney, J., et al. Backbone modifications of HLA-A2-restricted antigens induce diverse binding and T cell activation outcomes. J. Am. Chem. Soc. 143(17), 6470-6481 (2021).

    2. Chen, D., Hu, C., Hong, Y., et al. T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus. J. Transl. Med. 23(1), 846 (2025).