A derivative of semaglutide
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Hormones & Receptors
GLP

des-(7-13) Semaglutide

Item No. 44040

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,8S,16S,19S,22S,27S,33S,36S,39S,42S,69S)-2-((1H-imidazol-4-yl)methyl)-42-((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-12-(3-guanidinopropyl)-33-(hydroxyamino)-6-(2-(hydroxyamino)acetamido)-1-imino-18-isobutyl-15-isopropyl-24-methyl-7,10,13,16,19,22,25,28,31,32-decaoxo-2,8,11,14,17,20,23,26,29-nonaazahexatriacontan-36-amido)-33-(3-amino-3-oxopropyl)-19-benzyl-27-(hydroxyamino)-16-((R)-1-hydroxyethyl)-22-isobutyl-5,5,36,39-tetramethyl-1,6,11,12,15,18,21,24,28,29,32,35,38,41,48,57,66,71-octadecaoxo-50,53,59,62-tetraoxa-3,4,7,14,17,20,23,31,34,37,40,47,56,65,70-pentadecaazaheptaoctacontane-8,69,87-tricarboxylic acid
Molecular Formula
C156H246N38O45
Formula Weight
3373.9
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C(C)(C)NC([C@H](CC1=CNC=N1)N[H])=O)N[C@@H](CCC(O)=O)C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)([H])[C@@H](C)CC)=O)CC4=CC=CC=C4)=O)=O)=O)C)=O)C)=O)=O)=O)=O)CC(C)C)=O)CC5=CC=CC=C5)=O)=O)=O
InChi Code
InChI=1S/C156H246N38O45/c1-15-92(8)131(150(231)177-95(11)135(216)185-116(78-99-80-169-103-47-37-36-46-101(99)103)146(227)187-113(75-90(4)5)147(228)192-130(91(6)7)149(230)184-105(50-41-65-168-155(161)162)138(219)170-82-120(199)178-104(49-40-64-167-154(159)160)137(218)173-85-129(212)213)193-148(229)115(77-98-44-32-29-33-45-98)188-143(224)110(57-62-128(210)211)183-142(223)106(48-38-39-63-164-123(202)86-238-72-71-237-69-67-166-124(203)87-239-73-70-236-68-66-165-118(197)59-54-111(152(233)234)180-119(198)51-34-26-24-22-20-18-16-17-19-21-23-25-27-35-52-125(204)205)181-134(215)94(10)175-133(214)93(9)176-141(222)109(53-58-117(158)196)179-121(200)83-171-139(220)107(55-60-126(206)207)182-144(225)112(74-89(2)3)186-145(226)114(76-97-42-30-28-31-43-97)189-151(232)132(96(12)195)191-122(201)84-172-140(221)108(56-61-127(208)209)190-153(235)156(13,14)194-136(217)102(157)79-100-81-163-88-174-100/h28-33,36-37,42-47,80-81,88-96,102,104-116,130-132,169,195H,15-27,34-35,38-41,48-79,82-87,157H2,1-14H3,(H2,158,196)(H,163,174)(H,164,202)(H,165,197)(H,166,203)(H,170,219)(H,171,220)(H,172,221)(H,173,218)(H,175,214)(H,176,222)(H,177,231)(H,178,199)(H,179,200)(H,180,198)(H,181,215)(H,182,225)(H,183,223)(H,184,230)(H,185,216)(H,186,226)(H,187,227)(H,188,224)(H,189,232)(H,190,235)(H,191,201)(H,192,228)(H,193,229)(H,194,217)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,233,234)(H4,159,160,167)(H4,161,162,168)/t92-,93-,94-,95-,96+,102-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,130-,131-,132-/m0/s1
InChi Key
KWIMCKPJZOWSTP-BWAGTDNISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $138

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    5 mg

    $620

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    Product Description

    des-(7-13) Semaglutide is a derivative of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide (Item Nos. 40231 | 29969 | 40170) that does not contain amino acids 7-13, which correspond to amino acids 13-19 in GLP-1 and includes two residues important for GLP-1R interaction.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adelhorst, K., Hedegaard, B.B., Knudsen, L.B., et al. Structure-activity studies of glucagon-like peptide-1. The Journal of Biological Chemisty 69(9), 6275-6278 (1994).

    2. Cheang, J.Y., and Moyle, P.M. Glucagon-like peptide-1 (GLP-1)-based therapeutics: Current status and future opportunities beyond type 2 diabetes. ChemMedChem 13(7), 662-671 (2018).