A peptide fragment of IκBα
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IκBα (20-39) (human) (trifluoroacetate salt)

Item No. 44044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • NFKBIA
  • NF-κB Inhibitor α
Molecular Formula
C98H167N31O35S • XCF3COOH
Formula Weight
2371.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
LKKERLLDDRHDSGLDSMKD-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
[H]N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC(O)=O)=O)=O)CCSC)=O)=O)CC(O)=O)=O)=O)=O)=O)CC(O)=O)=O)CC1=CN=CN1)=O)=O)CC(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C98H167N31O35S.C2HF3O2/c1-47(2)32-52(102)78(145)113-53(18-10-13-26-99)80(147)114-54(19-11-14-27-100)81(148)118-58(23-24-72(133)134)85(152)116-56(21-16-29-108-97(103)104)82(149)120-61(34-49(5)6)88(155)121-62(35-50(7)8)89(156)124-65(38-74(137)138)92(159)126-64(37-73(135)136)91(158)117-57(22-17-30-109-98(105)106)83(150)122-63(36-51-42-107-46-111-51)90(157)125-66(39-75(139)140)93(160)128-69(44-130)79(146)110-43-71(132)112-60(33-48(3)4)87(154)123-67(40-76(141)142)94(161)129-70(45-131)95(162)119-59(25-31-165-9)86(153)115-55(20-12-15-28-101)84(151)127-68(96(163)164)41-77(143)144;3-2(4,5)1(6)7/h42,46-50,52-70,130-131H,10-41,43-45,99-102H2,1-9H3,(H,107,111)(H,110,146)(H,112,132)(H,113,145)(H,114,147)(H,115,153)(H,116,152)(H,117,158)(H,118,148)(H,119,162)(H,120,149)(H,121,155)(H,122,150)(H,123,154)(H,124,156)(H,125,157)(H,126,159)(H,127,151)(H,128,160)(H,129,161)(H,133,134)(H,135,136)(H,137,138)(H,139,140)(H,141,142)(H,143,144)(H,163,164)(H4,103,104,108)(H4,105,106,109);(H,6,7)/t52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-;/m0./s1
InChi Key
YPNIEGHLOSKJTK-ZTECCJMMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $372

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    10 mg

    $660

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    Product Description

    IκBα (20-39) is a peptide fragment of the N-terminal signal-receiving domain of IκBα (Item No. 43691), which is an inhibitor of NF-κB and a member of the IκB family of proteins.1,2 It contains several post-translational modification sites that regulate IκBα activity, including the phosphorylation sites Ser32 and Ser36, the ubiquitination sites Lys21 and Lys22, and the SUMOylation sites Lys21 and Lys38.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Majdalawieh, A., and Ro, H.-S. Regulation of IκBα function and NF-κB signaling: AEBP1 is a novel proinflammatory mediator in macrophages. Mediators Inflamm. 823821 (2010).

    2. Wang, X., Peng, H., Huang, Y., et al. Post-translational modifications of IκBα: The state of the art. Front. Cell Dev. Biol. 8, 574706 (2020).