A GPX4R152H activator
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DEL-I25

Item No. 44052

Product Insert (PDF)
Technical Information
Formal Name
5-amino-N-[1-[2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)acetyl]-3-azetidinyl]-2-pyridinepropanamide
CAS Number
3036889-54-7
Molecular Formula
C21H23N5O3
Formula Weight
393.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N1CC(C1)NC(CCC2=NC=C(C=C2)N)=O)CN(CC3=C4C=CC=C3)C4=O
InChi Code
InChI=1S/C21H23N5O3/c22-15-5-6-16(23-9-15)7-8-19(27)24-17-11-25(12-17)20(28)13-26-10-14-3-1-2-4-18(14)21(26)29/h1-6,9,17H,7-8,10-13,22H2,(H,24,27)
InChi Key
QJHULIVSOFPRHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $35

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    5 mg

    $158

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    10 mg

    $298

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    25 mg

    $656

    Add
    Product Description

    DEL-I25 is an activator of glutathione peroxidase 4 (GPX4) containing the loss-of-function mutation R152H (GPX4R152H).1 It selectively binds to GPX4R152H over wild-type GPX4 (Kds = 2 and 110 µM, respectively). DEL-I25 increases the viability of fibroblasts expressing GPX4R152H isolated from patients with spondylometaphyseal dysplasia (SSMD; EC50 = 2 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H., Forouhar, F., Saneto, R.P., et al. Selective small-molecule activator of patient-derived GPX4 variant. ACS Chem Biol. 20(5), 1107-1122 (2025).