An ionizable cationic lipid
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Lipid C16-C

Item No. 44085

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-(2-(4-(2-(2-(2-(bis(2-hydroxyhexadecyl)amino)ethoxy)ethoxy)ethyl)piperazin-1-yl)ethyl)-26-(2-hydroxyhexadecyl)-20,23-dioxa-17,26-diazadotetracontane-15,28-diol
CAS Number
2639634-86-7
Molecular Formula
C98H201N5O9
Formula Weight
1593.7
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
OC(CN(CCOCCOCCN(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O)CCN1CCN(CC1)CCOCCOCCN(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O)CCCCCCCCCCCCCC
InChi Code
InChI=1S/C98H201N5O9/c1-6-11-16-21-26-31-36-41-46-51-56-61-66-94(104)89-101(78-82-110-86-88-112-84-80-103(92-97(107)69-64-59-54-49-44-39-34-29-24-19-14-9-4)93-98(108)70-65-60-55-50-45-40-35-30-25-20-15-10-5)76-75-99-71-73-100(74-72-99)77-81-109-85-87-111-83-79-102(90-95(105)67-62-57-52-47-42-37-32-27-22-17-12-7-2)91-96(106)68-63-58-53-48-43-38-33-28-23-18-13-8-3/h94-98,104-108H,6-93H2,1-5H3
InChi Key
AFXLHIXDLDFTAT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $116

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    5 mg

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    10 mg

    $521

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    Product Description

    Lipid C16-C is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid C16-C selectively traffic to mouse liver and spleen over the lungs, kidneys, lymph nodes, and heart. LNPs containing lipid C16-C and encapsulating mRNA encoding HER2-targeting chimeric antigen receptor (CAR) induce CAR expression in human macrophages ex vivo and induce cytotoxicity in HER2-expressing SKOV3 ovarian cancer cells in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mukalel, A.J., Tylek, T., O’Brien, E., et al. Bioinspired oxidized mRNA lipid nanoparticles for ex vivo engineering of chimeric antigen receptor macrophages targeting solid tumors. bioRxiv [Preprint] (2025).