A molecular glue GSPT1 degrader
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MRT2359

Item No. 44120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-fluoro-5-(trifluoromethoxy)phenyl]-carbamic acid, [2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindol-5-yl] methyl ester
CAS Number
2803881-11-8
Molecular Formula
C22H17F4N3O6
Formula Weight
495.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
FC(F)(F)OC1=CC=C(F)C(NC(OCC(C=C23)=CC=C3CN(C2=O)C4CCC(NC4=O)=O)=O)=C1
InChi Code
InChI=1S/C22H17F4N3O6/c23-15-4-3-13(35-22(24,25)26)8-16(15)27-21(33)34-10-11-1-2-12-9-29(20(32)14(12)7-11)17-5-6-18(30)28-19(17)31/h1-4,7-8,17H,5-6,9-10H2,(H,27,33)(H,28,30,31)
InChi Key
HNTGMIGBGVFOBT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $126

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    10 mg

    $239

    Add

    25 mg

    $502

    Add

    50 mg

    $816

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    Product Description

    MRT2359 is a molecular glue degrader of G1 to S phase transition protein 1 homolog (GSPT1).1 It promotes the interaction between the E3 ubiquitin ligase cereblon and GSPT1, inducing the degradation of GSPT1 and termination of protein synthesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duffy, M.J., Tang, M., and Crown, J. MYC as a target for cancer treatment: From undruggable to druggable? Target Oncol. (2025).