A synthetic derivative of melanin
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Synthetic Melanin

Item No. 44132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,8-dimethyl-2,7-dihydrobenzo[1,2,3-cd:4,5,6-c'd']diindole-4,5,9,10-tetraone
CAS Number
8049-97-6
Molecular Formula
C18H10N2O4
Formula Weight
318.3
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(C1=O)=C2C(C(C(C3=O)=C4C5=CNC4=C(C)C3=O)=CN2)=C5C1=O
InChi Code
InChI=1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
InChi Key
XUMBMVFBXHLACL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 mg

    $131

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    250 mg

    $229

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    500 mg

    $426

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    Cayman Chemical
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    Product Description

    Synthetic melanin is a synthetic derivative of the endogenous UV-absorbing compound melanin.1 It inhibits IgE-induced RBL-2H3 mast cell degranulation (IC50 = 39.8 µg/µl). Lipid nanoparticles (LNPs) encapsulating synthetic melanin, in combination with radiation, reduce tumor volume without affecting body weight in a BxPC-3 pancreatic cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawamoto, Y., Kondo, H., Hasegawa, M., et al. Inhibition of mast cell degranulation by melanin. Biochem. Pharmacol. 163, 178-193 (2019).

    2. Wang, J., Chai, J., Liu, L., et al. Dual-functional melanin-based nanoliposomes for combined chemotherapy and photothermal therapy of pancreatic cancer. RSC Adv. 9(6), 3012-3019 (2019).