An ionizable cationic and chloroquine-derived lipid
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CF3-2N6-UC18

Item No. 44140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N1-di-9-octadecen-1-yl-N6-[7-(trifluoromethyl)-4-quinolinyl]-1,6-hexanediamine
CAS Number
3042854-95-2
Molecular Formula
C52H88F3N3
Formula Weight
812.3
Purity
≥90%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCC/C=C\CCCCCCCCN(CCCCCCCC/C=C\CCCCCCCC)CCCCCCNC1=C(C=CC(C(F)(F)F)=C2)C2=NC=C1
InChi Code
InChI=1S/C52H88F3N3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-32-36-44-58(45-37-33-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-38-34-31-35-42-56-50-41-43-57-51-47-48(52(53,54)55)39-40-49(50)51/h17-20,39-41,43,47H,3-16,21-38,42,44-46H2,1-2H3,(H,56,57)/b19-17-,20-18-
InChi Key
RQICHMVWIDRVQC-CLFAGFIQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    CF3-2N6-UC18 is an ionizable cationic and chloroquine-derived lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing CF3-2N6-UC18 and encapsulating a Cy5-mRNA reporter exhibit increased cellular uptake via micropinocytosis and improved endosomal escape compared with LNPs containing non-chloroquine-derived lipids. LNPs containing CF3-2N6-UC18 selectively accumulate in mouse lymph nodes after intravenous administration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Wu, J., Wang, N., et al. Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing. Nat. Commun. 16(1), 4241 (2025).