An amine-functionalized hydrophilic polymer
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N,N-ditetradecylamine-pSar50-H

Item No. 44167

Product Insert (PDF)
Technical Information
Formal Name
2-(methylamino)-N,N-ditetradecylacetamide
Synonyms
  • Dimyristylamine-pSar50-H
  • N,N-ditetradecylamine-Polysarcosine50
  • N,N-ditetradecylamine-pSar50-H
  • (C14)2-pSar50-H
Molecular Formula
(C3H5NO)nC28H59N
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
SMILES
O=C(CN([H])C)N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $212

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    10 mg

    $358

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    25 mg

    $812

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    This product has been produced by

    Curapath
    Cayman Chemical
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    Product Description

    N,N-ditetradecylamine-pSar50-H is an amine-functionalized hydrophilic polymer and a polysarcosine-conjugated form of ditetradecylamine. Polysarcosines (pSars) have been used as alternatives to PEGylated lipids in lipid nanoparticles (LNPs).1 Liposomes containing pSar exhibit similar physicochemical properties in vitro to those containing PEGylated lipids but do not undergo the accelerated blood clearance (ABC) phenomenon and show reduced immunogenicity in rats.2 For more information, please see Curapath's white paper: Polysarcosine (pSar) a safer, more effective alternative to poly-ethylene glycol (PEG).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nogueira, S.S., Schlegel, A., Maxeiner, K., et al. Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery. ACS Appl. Nano Mater. 3(11), 10634-10645 (2020).

    2. Son, K., Ueda, M., Taguchi, K., et al. Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes. J. Control Release 322, 209-216 (2020).